ANTITOXINS.

The Dose of Antitoxins

? columns the tendency to draw far reaching conclusions on inadequate grounds purporting to be based on experimental data, I take the opportunity offered by Major Carr-Whiteis interesting paper " Is Antivenene of any value in Cobra Poisoning, in your current number to again draw attention to this important matter in relation to the anti-toxins, taking for illustration anti-venene, anti-tet ino-...

Toxins and Antitoxins of Bacillus Dysenteriæ Shiga

With the methods which have been described we have separated an exotoxin and an endotoxin from cultures of the Shiga dysenteric bacillus. The study of the nature and effect of the poison of this microorganism is thus simplified. The two toxins are physically and biologically distinct. The exotoxin is relatively heat-labile, arises in the early period of growth, and yields an antiexotoxic immune...

Preparation of standard Clostridial antitoxins in sheep

One cannot rule them all: Are bacterial toxins-antitoxins druggable?

Type II (proteic) toxin-antitoxin (TA) operons are widely spread in bacteria and archaea. They are organized as operons in which, usually, the antitoxin gene precedes the cognate toxin gene. The antitoxin generally acts as a transcriptional self-repressor, whereas the toxin acts as a co-repressor, both proteins constituting a harmless complex. When bacteria encounter a stressful environment, TA...

Neutralization of Clostridium difficile toxin by Clostridium sordellii antitoxins.

Neutralization of Clostridium difficile toxin by Clostridium sordellii antitoxin was studied by cytotoxicity assay in tissue culture. The sources of toxin were stools from two patients with pseudomembranous colitis and a culture filtrate of C. difficile isolated from one of the patients. C. sordellii antitoxin was available either in monovalent form or as gas gangrene polyvalent antitoxin. The ...